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Expanding successful diagnostic methods

 

Taking successful diagnostic methods as a basis, we are developing new tests for further resistance traits. These should deliver results in less than three hours and require only simple laboratory equipment.

Project description (ongoing research project)

Molecular biology tests have become established in everyday clinical practice because they recognise many resistance genes in pathogens. Taking successful methods as a basis, we intend to develop further tests that can detect additional known resistance traits, but are also able to detect new resistance variants. The tests are based on biochemical, immunological and rapid culture methods, depending on the molecular property that is responsible for resistance and is therefore to be identified. We are focusing on difficult-to-treat multi-resistant bacteria, in particular hospital-acquired bacterial species such as Enterobacteraciae, Acinetobacter baumannii and Pseudomonas aeruginosa. The tests are expected to deliver results in less than three hours and require only simple laboratory equipment.

Background

There is a great need for faster diagnostic tests in both veterinary and human medicine. These would increase cure and survival rates, while at the same time helping to fight resistance by enabling a more targeted use of antibiotics.

Aim

Our aim is to develop and validate the tests rapidly, which means having them available for clinical use within the three years this project lasts. The tests will screen for several non-related antibiotic resistance traits in difficult-to-treat bacteria.

Relevance

The tests are designed to detect resistances of great medical importance and are suitable for both human and veterinary medicine. Since they also require only simple laboratory equipment, they can be used quickly both in Switzerland and internationally.

Original title

Rapid diagnostic tests for detection of antibiotic resistance in clinically-significant Gram-negative bacteria

Project leaders

  • Prof. Patrice Nordmann, Molekular und Mikrobiologie, Université de Fribourg

 

 

Further information on this content

 Contact

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Prof. Patrice Nordmann Molekular und Mikrobiologie
Departement Medizin
Université de Fribourg
Route Albert Gockel 3 1700 Fribourg +41 26 300 95 81 patrice.nordmann@unifr.ch